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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Professor, Department of Medicine

Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Co- Director, Division of Precision Medicine

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Claudio Quiros, Adalberto; Coudray, Nicolas; Yeaton, Anna; Yang, Xinyu; Liu, Bojing; Le, Hortense; Chiriboga, Luis; Karimkhan, Afreen; Narula, Navneet; Moore, David A; Park, Christopher Y; Pass, Harvey; Moreira, Andre L; Le Quesne, John; Tsirigos, Aristotelis; Yuan, Ke

Nature communications. 2024 Jun 11; 15(1):4596

Subudhi, Ipsita; Konieczny, Piotr; Prystupa, Aleksandr; Castillo, Rochelle L; Sze-Tu, Erica; Xing, Yue; Rosenblum, Daniel; Reznikov, Ilana; Sidhu, Ikjot; Loomis, Cynthia; Lu, Catherine P; Anandasabapathy, Niroshana; Suárez-Fariñas, Mayte; Gudjonsson, Johann E; Tsirigos, Aristotelis; Scher, Jose U; Naik, Shruti

Immunity. 2024 May 14;

Tiniakou, Ioanna; Hsu, Pei-Feng; Lopez-Zepeda, Lorena S; Garipler, Görkem; Esteva, Eduardo; Adams, Nicholas M; Jang, Geunhyo; Soni, Chetna; Lau, Colleen M; Liu, Fan; Khodadadi-Jamayran, Alireza; Rodrick, Tori C; Jones, Drew; Tsirigos, Aristotelis; Ohler, Uwe; Bedford, Mark T; Nimer, Stephen D; Kaartinen, Vesa; Mazzoni, Esteban O; Reizis, Boris

Science immunology. 2024 Apr 12; 9(94):eadi1023

Pillai, Ray; LeBoeuf, Sarah E; Hao, Yuan; New, Connie; Blum, Jenna L E; Rashidfarrokhi, Ali; Huang, Shih Ming; Bahamon, Christian; Wu, Warren L; Karadal-Ferrena, Burcu; Herrera, Alberto; Ivanova, Ellie; Cross, Michael; Bossowski, Jozef P; Ding, Hongyu; Hayashi, Makiko; Rajalingam, Sahith; Karakousi, Triantafyllia; Sayin, Volkan I; Khanna, Kamal M; Wong, Kwok-Kin; Wild, Robert; Tsirigos, Aristotelis; Poirier, John T; Rudin, Charles M; Davidson, Shawn M; Koralov, Sergei B; Papagiannakopoulos, Thales

Science advances. 2024 Mar 29; 10(13):eadm9859

Liu, Bojing; Polack, Meaghan; Coudray, Nicolas; Quiros, Adalberto Claudio; Sakellaropoulos, Theodoros; Crobach, Augustinus S L P; van Krieken, J Han J M; Yuan, Ke; Tollenaar, Rob A E M; Mesker, Wilma E; Tsirigos, Aristotelis

bioRxiv : the preprint server for biology. 2024 Mar 21;

Contreras Yametti, Gloria P; Robbins, Gabriel; Chowdhury, Ashfiyah; Narang, Sonali; Ostrow, Talia H; Kilberg, Harrison; Greenberg, Joshua; Kramer, Lindsay; Raetz, Elizabeth; Tsirigos, Aristotelis; Evensen, Nikki A; Carroll, William L

Leukemia & lymphoma. 2024 Jan; 65(1):78-90

Murphy, Dylan; Salataj, Eralda; Di Giammartino, Dafne Campigli; Rodriguez-Hernaez, Javier; Kloetgen, Andreas; Garg, Vidur; Char, Erin; Uyehara, Christopher M; Ee, Ly-Sha; Lee, UkJin; Stadtfeld, Matthias; Hadjantonakis, Anna-Katerina; Tsirigos, Aristotelis; Polyzos, Alexander; Apostolou, Effie

Nature structural & molecular biology. 2024 Jan; 31(1):125-140

Zavitsanou, Anastasia-Maria; Pillai, Ray; Hao, Yuan; Wu, Warren L; Bartnicki, Eric; Karakousi, Triantafyllia; Rajalingam, Sahith; Herrera, Alberto; Karatza, Angeliki; Rashidfarrokhi, Ali; Solis, Sabrina; Ciampricotti, Metamia; Yeaton, Anna H; Ivanova, Ellie; Wohlhieter, Corrin A; Buus, Terkild B; Hayashi, Makiko; Karadal-Ferrena, Burcu; Pass, Harvey I; Poirier, John T; Rudin, Charles M; Wong, Kwok-Kin; Moreira, Andre L; Khanna, Kamal M; Tsirigos, Aristotelis; Papagiannakopoulos, Thales; Koralov, Sergei B

Cell reports. 2023 Nov 28; 42(11):113295