Professor, Department of Medicine
Professor, Department of Pathology
Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).
Co- Director, Division of Precision Medicine
Director, Applied Bioinformatics Laboratories
Director, Clinical Informatics, Molecular Pathology Lab
PhD from New York University
Nature communications. 2024 Jun 11; 15(1):4596
Science immunology. 2024 Apr 12; 9(94):eadi1023
Science advances. 2024 Mar 29; 10(13):eadm9859
bioRxiv : the preprint server for biology. 2024 Mar 21;
Leukemia & lymphoma. 2024 Jan; 65(1):78-90
Nature structural & molecular biology. 2024 Jan; 31(1):125-140
Cell reports. 2023 Nov 28; 42(11):113295